Endocrine Abstracts

G protein-coupled receptors (GPCRs) are the largest family of mammalian receptors, modulating most aspects of endocrine homeostasis. GPCRs can associate to form dimers and higher order oligomers, acting to diversify receptor functionality. Most studies have explored the functional significance of GPCR dimerization in vitro and we have recently demonstrated the functional relevance of GPCR dimerization in vivo. Using the LH receptor (LHR), we have shown that t...

The D2 dopamine receptor (D2R) is a G protein-coupled receptor (GPCR) known to have key roles in neurotransmission, hypothalamic-pituitary hormone release and glucose homeostasis. Thus, this receptor is a therapeutic target in schizophrenia, neurodegenerative disorders, endocrine tumours and even diabetes. As for many GPCRs, D2R can associate with itself as homodimers or heterodimers with distinct receptors. The balance between monomers, homodimers and heterodimers of D2R has ...

Introduction: The developmental stages of the ovarian follicle are characterized by changes of gonadotropin and steroid hormone receptor expression and their potential interactions on the surface of granulosa cells. In this study in vitro, we aim to evaluate whether the co-existing follicle-stimulating hormone receptor (FSHR) and G protein-coupled estrogen receptor (GPER) form heteromers, which may play role in selecting the dominant ovarian follicle.<p class="abs...

During the menstrual cycle, selection of the dominant follicle is characterized by changes of gonadotropin and steroid hormone receptor expression. We aim to evaluate whether co-existing follicle-stimulating hormone receptor (FSHR) and G protein-coupled estrogen receptor (GPER) form heterodimers, suggesting their role in ovarian follicle selection. FSHR-GPER dimerization was evaluated in transfected HEK293 cells in vitro by bioluminescence resonance energy transfer (B...